Search results for "vascular senescence"
showing 2 items of 2 documents
Female Vascular Senescence
2012
Long before the existence of cardiovascular imaging, Sir William Osler axiom that “man is as old as his arteries”. Followed by several physicians for decades, this aphorism has been widely confirmed by studies demonstrating that risk factors for cardiovascular disease increase as we age (Cooper et al., 1994; Lakatta & Levy, 2003). Nevertheless, a flaw in this statement is the generalization that men and women age similarly. Much data from clinical and basic research have established that vascular aging in women does not follow the same chronology as in men (Shaw et al., 2006; Pereira et al., 2010; Takenouchi et al., 2009). If known risk factors that influence cardiovascular aging are exclud…
Vascular aging in rodent models: contrasting mechanisms driving the female and male vascular senescence
2021
Increasing scientific interest has been directed to sex as a biological and decisive factor on several diseases. Several different mechanisms orchestrate vascular function, as well as vascular dysfunction in cardiovascular and metabolic diseases in males and females. Certain vascular sex differences are present throughout life, while others are more evident before the menopause, suggesting two important and correlated drivers: genetic and hormonal factors. With the increasing life expectancy and aging population, studies on aging-related diseases and aging-related physiological changes have steeply grown and, with them, the use of aging animal models. Mouse and rat models of aging, the most…